The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome (6, 7), a crucial contributor to tissue injury via converting downstream inflammatory cytokines IL-1β and IL-18 into their corresponding active forms, has been increasingly implicated in the pathogenesis of various kidney diseases, including both tubulointerstitial and glomerular diseases (8). This evidence concerns the gene NLRP3 and kidney disorder.