IFIT1 and infection: In the initial phase (between 0 and 24 h post infection), ~25 ISGs are transiently induced by extracellular HIV vesicles in a cell-type specific manner, with the most up-regulated ISGs in MDMs being Viperin (also known as RSAD2), IFIT1, IFIT2, and IFIT3 (124, 171), and ISG15, IFIT1, and IFIT2 in MDDCs (160).