RNF5 and neoplasm: In agreement with the findings of the aforementioned study by Tanoue et al. (85), experimental intestinal colonization of germ-free mice with 11 bacterial strains predominant in the gut microbiome of mice lacking the Rnf5 gene, including B. rodentium, was found to establish anti-tumor immunity according to restriction of growth of an experimental tumor (melanoma) (86).