Moreover, we hypothesized that the humoral aberrancy is confined to α-syn and to further examine whether alterations are a general amyloidogenic tendency, we investigated autoantibody subclass levels toward serine-129-phosphorylated α-syn, and the closely related β- and γ-syn, together with plasma levels of the dementia-associated amyloidogenic proteins amyloid-β (Aβ) and tau. The gene discussed is MAPT; the disease is dementia.