IRAK3 and rheumatoid arthritis: Several studies have proven significant associations between a particular SNP in one of the resulting IRAK3 variants and unbalanced immune reactions, including (i) asthma (53, 54), (ii) sepsis (55) and sepsis-induced acute lung injury (56), as well as (iii) a positive response to treatment in rheumatoid arthritis (57), and (iv) protection against Bordetella pertussis after vaccination (58).