CEACAM8 and cancer: In cancer patients, G-MDSCs are CD11b+ CD14− CD66b+ CD15hi expressing-cells that are enriched in the low-density neutrophils (LDNs) fraction present within the peripheral blood mononuclear cell (PBMCs) ring, unlike normal density neutrophils (NDNs), which are found in the granulocyte pellet of ficolled blood (46–49).