Mounting evidence indicates that IFNγ and GM-CSF, two cytokines abundantly present in early-stage human lung tumors, are essential for the differentiation of CD11b+ CD15hi CD66b+ CD16int/low CD10− bone marrow neutrophil progenitors into anti-tumor CD10+ mature MHC-II+ antigen presenting neutrophils, known as “APC-like hybrid neutrophils” (114, 115). Here, MME is linked to neoplasm.