Rapid recruitment of CD8 T cells to the liver stages in the first 4 h after T cell transfer may be the result of the specific experimental set-up as it is expected that immediately after intravenous injection, large numbers of T cells would be passing through the liver increasing chances of T cells finding the infection site (56), and that the number of liver-resident CD8 T cells tends to reach a steady state at 2–3 h after T cell transfer (57, James O'Connor and Ian Cockburn, in preparation). Here, CD8A is linked to infection.