Studies from human and mammals studies have shown that activation of GLP-1R could reduce the triglyceride (TG) content, decrease the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and improve hepatic steatosis (Cuthbertson et al., 2012; Trevaskis et al., 2012). The gene discussed is GPT; the disease is Hepatic steatosis.