Our results and other recent reports have demonstrated that TREM-1 signaling contributes to proinflammatory pathway activation in liver injury, fibrosis, alcoholic liver disease, and NAFLD (Nguyen-Lefebvre et al., 2018; Rao et al., 2019; Tornai et al., 2019). This evidence concerns the gene TREM1 and metabolic dysfunction-associated steatotic liver disease.