A recent study found that knockdown of TREM-1 can ameliorate the inflammatory response and lipid accumulation of nonalcoholic fatty liver disease (NAFLD) mice inactivation of TREM-1/nuclear factor-kappa B (NF-κB) and TREM-1/PI3K/AKT axis (Rao et al., 2019). This evidence concerns the gene AKT1 and metabolic dysfunction-associated steatotic liver disease.