There is a well-defined correlation between OSA and increased risk for T2D due to the presence of decrease glucose tolerance and insulin sensitivity, with a positive correlation between severity of OSA and poorer glucose regulation (Punjabi et al., 2004; Bostros et al., 2009; Aronsohn et al., 2010; Zhang et al., 2018). This evidence concerns the gene INS and obstructive sleep apnea syndrome.