MAPT and Alzheimer disease: First, neuroimaging studies confirmed that prior to the hypometabolism typically described in preclinical stages of AD, brain regions most vulnerable to Aβ and tau accumulation are uniquely reliant on glucose for normal brain function and display increased glucose consumption at a young age (Edison et al., 2007; Mosconi et al., 2008; Vaishanavi et al., 2010; Vlassenko et al., 2010; Oh et al., 2016; Hanseeuw et al., 2017; Adams et al., 2018).