Because dysfunction of p62 as well as CB2 receptors are involved in neurodegenerative diseases, inflammation, cancer and bone biology (Pacher and Mechoulam, 2011; Duran et al., 2016; Sanchez-Martin and Komatsu, 2018), it has to be clarified in future experiments if the complex formation of p62 and CB2 is involved in these pathophysiologic functions. This evidence concerns the gene SQSTM1 and neurodegenerative disease.