SOD1 and amyotrophic lateral sclerosis: Melatonin has been shown to confer neuroprotection in ALS patients and Cu/Zn superoxide dismutase (SOD1) mice models, likely by decreasing systemic oxidative stress, caspase activation, and by increasing ATP availability to increase cell repair mechanisms to limit neuronal death (Weishaupt et al., 2006; Zhang et al., 2013).