For our UP genes we found 10/23 (43%) that overlapped (TNFSF10, DKK1, GRP, CALHM2, MME, ALDH1A2, CXCL14, PPP1R17, TMEM255A, HAPLN1) and 17/70 (24%) DN genes (SHISA2, DNAH11, SERPIND1, SCN1A, APOL1, HP, ERP27, SERPINA3, STXBP6, CFAP70, PARVG, GDA, PCP4, NTRK1, TMC5, STOML3, RARRES3) suggesting some potential AD relevance. This evidence concerns the gene APOL1 and Alzheimer disease.