For our UP genes we found 10/23 (43%) that overlapped (TNFSF10, DKK1, GRP, CALHM2, MME, ALDH1A2, CXCL14, PPP1R17, TMEM255A, HAPLN1) and 17/70 (24%) DN genes (SHISA2, DNAH11, SERPIND1, SCN1A, APOL1, HP, ERP27, SERPINA3, STXBP6, CFAP70, PARVG, GDA, PCP4, NTRK1, TMC5, STOML3, RARRES3) suggesting some potential AD relevance. The gene discussed is SCN1A; the disease is Alzheimer disease.