Zhu et al. reported that the expression of GluR1 as well as the neurons co-expressing brain-derived neurotrophic factor and GluR1 were downregulated in the hippocampal CA3 region of neuropathic pain mice, which was also correlated with the pain-related comorbid conditions (Zhu et al., 2017). This evidence concerns the gene GRIA1 and neuropathic pain.