The down-regulation of NR2B, GluR1, CaMKII and synaptic proteins in the hippocampal neurons are associated with learning-memory deficits and cognitive dysfunctions in Alzheimer’s disease (AD) animal models (Liu et al., 2016; Mariani et al., 2017; Zhu et al., 2018). Here, GRIN2B is linked to early-onset autosomal dominant Alzheimer disease.