ARHGAP15 and Cognitive impairment: On the other hand, mice mutants for the ARHGAP15 gene showed cognitive deficits due to impaired neuritogenesis in the hippocampus [54], and a de novo synonymous mutation in this gene was found in a patient with sporadic autism [55], followed by a recent report of a chromatin interaction of a schizophrenia GWAS locus with the promoter of the ARHGAP15 gene [8].