GZMB and schizophrenia: In this example, while there is evidence that VRK2 might play a role in schizophrenia, the variant’s location adjacent to Enh5–Enh8 region suggests that the enhancers in the vicinity of the identified risk variants also regulates BCL11A, with larger effect on its expression level than that of VRK2. Therefore, the hypothesis-free annotation of GRB targets has provided a more biologically plausible candidate gene at this locus.