ESR1 and rheumatoid arthritis: In addition, our genetic and functional results were also concordant with data of previous studies reporting that the presence of certain SNPs, microsatellites or even specific haplotypes within estrogen receptor genes is associated with bone mineral density and influences the risk of developing bone erosions66,67 affecting RA patients68 but also subjects diagnosed with other chronic inflammatory diseases69 and bone degenerative diseases70,71.