A sub-analysis of myeloid cells in CD45+ dense tumor regions demonstrated that in areas of immune cell enrichment, macrophages increased following R848 treatment from a mean of 0.55% to 8.08% of cells per region of interest (P < 0.01, n = 20 regions of interest (ROI)/group, Supplementary Fig. 3C). Here, PTPRC is linked to neoplasm.