Compared with vehicle-treated KxPxCx-engrafted mice, R848-treated animals demonstrated decreases in the E3 ubiquitin ligases Mafbx and Murf1, as well as the transcription factor Foxo1. Targeted array profiling of skeletal muscle was performed for 84 transcripts related to myogenesis and myopathy, comparing sham-operated animals to KxPxCx-bearing animals with and without R848 (Supplementary Fig. 5). Here, FOXO1 is linked to myopathy.