Downregulation of cellular Daxx in mouse cancer cell lines (B16BL6-CAR, B16F10-CAR, BNL-CAR, and Panc02 cells) and p53-mutant human cancer cell lines (MiaPaCa-2 and DU145 cells) by infection with Daxx-specific shRNA-expressing oncolytic adenovirus increased adenoviral replication (Fig. 1c). This evidence concerns the gene TP53 and infection.