Here, we found that HSP27 expression was strongly correlated with Daxx expression in human cancer cells and that enhanced viral replication was induced by HSP27 downregulation depending on the cellular p53 status; thus, HSP27 and HSP25 perform distinctly different roles in human and murine cancer cells (Supplementary Fig. 3, Figs. 2d, e, 3d). This evidence concerns the gene DAXX and cancer.