Furthermore, different mechanisms governed Daxx degradation in human and mouse cancer cells: human Daxx degradation induced by HSP27 downregulation was mainly the result of ubiquitin-independent proteasomal degradation; on the other hand, Daxx in BNL cells expressing HSP25 was not degraded by the proteasome, suggesting that mouse Daxx resists proteasomal degradation. This evidence concerns the gene HSPB1 and cancer.