Next, we demonstrated that the decrease in Daxx levels following HSP27 downregulation in human cancer cells resulted from decreased binding of ETS1 and SP1 to the Daxx promoter (Fig. 3e, left, middle), whereas HSP25 downregulation in murine cells increased ETS1 binding to the Daxx promoter (Fig. 3e, right). Here, ETS1 is linked to cancer.