The decrease in Daxx levels after HSP27 downregulation in human cancer cells was at least in part due to the proteasomal degradation of Daxx (Fig. 2f, left); in contrast, the decrease in Daxx levels in mouse BNL cells overexpressing HSP25 was not related to proteasomal degradation (Fig. 2f, right). The gene discussed is HSPB1; the disease is cancer.