We previously reported CAR and Wnt/β-catenin signaling–dependent transcriptional effects at the pluripotency-associated Dlk1-Dio3 imprinted gene cluster noncoding RNAs in the liver of mice treated with tumor-promoting doses of PB (Lempiainen et al, 2013; Pouche et al, 2017). The gene discussed is DIO3; the disease is neoplasm.