Significant evidence support functional implication of Stat family members in hepatocarcinoma and cross-interactions with some of the core genes and pathways identified from PB-mediated changes in RNA or open chromatin effects (such as Src and TGF-β), ultimately consistent with the early tumor promotion relevance of this cluster of TF motifs in B6C3F1 mice (see the Discussion section). The gene discussed is TGFB1; the disease is neoplasm.