The down-regulation of DHSs containing Bcl6 and Bcl6b TF motifs (cluster 32) implies a reduction in Bcl6-mediated signaling in PB-mediated B6C3F1 mice and is consistent with the low levels of BCL6B expression that have been previously reported as a potential prognostic biomarker for HCC (Wang et al, 2015b). This evidence concerns the gene TF and hepatocellular carcinoma.