IKBKB and Autoimmunity: These ubiquitin chains act as a scaffold for the recruitment and activation of ubiquitin-binding proteins, which include the “master” protein kinases TAK1 and IKKβ that drive inflammatory mediator production, as well as other proteins like ABIN1 and A20 that restrict activation of the network to prevent the overproduction of these substances that can lead to autoimmunity and organ damage.