However, since these elevated auto-antibodies could also be only a response to some pathological conditions (such as autoimmune hypothyroidism, RPL unrelated to APS or smoking), but might not actually be pathological, further studies are needed to understand the pathophysiological local mechanism at the maternal-fetal interface related to the presence of aPL Abs in the amniotic fluid. This evidence concerns the gene FASLG and Hashimoto thyroiditis.