In particular, SFA overfeeding increased the mean methylation of 125 genes and PUFA overfeeding changed the mean methylation of 1797 genes, only 47 genes overlapped between the two diets, which ones were related to adipose tissue accumulation, obesity, FA uptake, transport, and lipid metabolism insulin resistance and inflammation pathways. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.