GNAS and diabetes mellitus: They compared the two diets MedDiet + EVOO and MedDiet + nuts with a low-fat control group during five-year follow-up and found that MedDiet + nuts favors a hypermethylation of cg01081346 in CPT1B/CHKB-CPT1B genes (Carnitine palmitoyltransferase 1B/Choline kinase-like, Carnitine palmitoyltransferase 1B) and MedDiet + EVOO induce hypomethylation in cg17071192 in GNAS/GNASAS genes GNAS/GNASAS (Guanine Nucleotide Binding Protein, G Protein), however both diets were associated with intermediate metabolism as well as improve genes involved in diabetes and inflammation pathways [18].