Furthermore, n-3 PUFA supplementation was accompanied by improved weight loss, which was associated with changes in the methylation pattern of one specific CpG site in CD36, a gene that encodes a membrane glycoprotein that plays a relevant role in lipid metabolism and may be implicated in obesity-related complications like glucose intolerance and T2D [19]. The gene discussed is CD36; the disease is obesity due to melanocortin 4 receptor deficiency.