SOX2 and infarction: Subsequent studies of individual lncRNAs playing a transcriptional or post-transcriptional regulatory role in DR pathogenesis and progression had been reported, including Maternally Expressed 3 (MEG3) [16], Myocardial Infarction Associated Transcript (MIAT) [17, 18], HOXA Distal Transcript Antisense RNA (HOTTIP) [19], Metastasis Associated Lung Adenocarcinoma Transcript 1(MALAT1) [20, 21], SOX2 Overlapping Transcript (Sox2-OT) [22], antisense non-coding RNA in the INK4 locus (ANRIL) [23] and BDNF Antisense RNA (BDNF-AS) [24].