When we divided all endometriosis patients into two groups: early staged group (stages I and II) and late staged group (stages III and IV), late staged EMS patients were found to produce increased levels of PF IL-8/12/17 (Fig. 2d, e, f) as compared to those from controls (11.30 ± 2.46 vs 26.37 ± 4.86, P = 0.0288), and the early staged EMS group showed higher secretion of PF IL-12 and IL-17 (Fig. 2e, f) (4.23 ± 0.59 vs 8.15 ± 1.50, P = 0.0220; 4.23 ± 0.59 vs 9.42 ± 2.62, P = 0.0356; 4.50 ± 0.61 vs 11.19 ± 3.10, P = 0.0406; 4.50 ± 0.61 vs 14.20 ± 5.24, P = 0.0499). This evidence concerns the gene CXCL8 and endometriosis.