To overcome this and to detect high confidence instances of differential gene regulation between the sexes, we further examined the sex-shared and sex-specific eGenes: we found 24 genes that are under germline regulatory control in only male HCC (Fig. 3c), including POGLUT1, which is an essential regulator of Notch signaling (Fig. 3d). Here, POGLUT1 is linked to hepatocellular carcinoma.