Genes involved in Notch and PI3K/AKT signaling were also found to be expressed in a sex-biased way in HCC tumors and overrepresented among the male-specific DEGs detected in the tumor vs. tumor-adjacent comparison, showing that sex-specific eQTLs and sex-specific dysregulated genes converge in canonical pathways. The gene discussed is AKT1; the disease is hepatocellular carcinoma.