Subgroup analyses of OS according to the allocation factors, including disease etiology (hepatitis C or non-hepatitis C), portal vein tumor thrombosis (presence or absence), and extrahepatic metastasis (presence or absence), did not show any superiorities of HAIC to sorafenib between the two groups (Fig. 3); however, in patients with a baseline AFP ≥400 ng/mL, the OS of the sorafenib group was significantly better than that of the HAIC group (HR, 2.86; 95% CI, 1.15–7.10; P = 0.018). The gene discussed is AFP; the disease is hepatitis C virus infection.