As MASM induced autophagy and increased autophagic flux within the cancer cells through PI3K/Akt/mTOR, Erk1/2 and p38 signaling, one strategy to exploit MASM in treatment of cancer could involve co-delivery of late stage autophagy inhibitor CQ with inhibitors specific to either PI3K or p38 signaling pathways. This evidence concerns the gene MAPK3 and cancer.