PADI4 and type 2 diabetes mellitus: When comparing the AGR components separately after 3 months, dsDNA levels were significantly higher in patients with IFG vs. NGR (p = 0.019) and in patients with T2DM vs. NGR (p = 0.045), whereas levels of MPO-DNA and PAD4 mRNA did not differ between the three AGR categories (Fig. 3).