The LR can predict 1242 target genes (5.74%), at best, among the other three methods, including the genes ABCD1, HPD, AMH, and ARAF, laying a solid foundation for the pathogenesis of diseases, such as Adrenoleukodystrophy, Hawkinsinuria, Persistent Mullerian Duct Syndrome, and Pallister-Killian Syndrome, using our LR [33,34,35,36]. This evidence concerns the gene HPD and X-linked adrenoleukodystrophy.