SKA2 and breast carcinoma: A clinical study comparing the effects of the drug tamoxifen versus tamoxifen plus breast radiotherapy, carried out on 71 lymph-node-negative (LNN) breast cancer patients, revealed that the up-regulation of miRNA-301 in co-operation with SKA2 (spindle kinetochore-associated complex subunit 2) increased proliferation, migration, invasion and tumour formation through the regulation of key signalling pathways including PTEN, FOXF2 and Col2A1 [42].