IL6R and Hepatic fibrosis: The HCV-induced downregulation of miR-449a and miR-107 correlates with increased CCL2 (a major inflammatory chemokine) and STAT3 phosphorylation expression by targeting components of the interleukin-6 receptor (IL-6R) complex, such as IL-6R and JAK1, respectively, in infected patients resulting in hepatic fibrosis [39].