EWSR1 generates a powerful oncogenic protein causing Ewing sarcoma [29], RET is a proto-oncogene well-known in hereditary medullary thyroid carcinoma NRP1 is known to be positively associated with the progression of breast cancer [30], POT1 is a known predisposing gene in malignant melanoma [31] and TG encodes the precursor of iodinated thyroid hormones and is associated with susceptibility to autoimmune thyroid diseases (AITD) [32]. The gene discussed is POT1; the disease is Ewing sarcoma.