HSPG2 and hepatocellular carcinoma: In support of the alteration of HCC invasion ability, miR-196a knockdown resulted in reduced stress fiber formation and actin staining in the cytoplasm of PLC cells (Figure 2F, the left panel), and higher levels of membranous zonula occludens-1 (ZO-1), a tight junction-associated protein (Figure 2F, the middle panel).