Aberrant promoter methylation of transcription factors, such as the CCAAT/enhancer-binding protein alpha (CEBPA), or TSG as CDKN2B (P15) and CDKN2A (P16), the adhesion molecule e-cadherin (CDH1) and the estrogen receptor (ER) [129] have been reported in either MDS and/or AML [129,130,131]. The gene discussed is ESR1; the disease is myelodysplastic syndrome.