High expression of CRHR2 and Ucn2 has also been described in human colonic mucosal cells from IBD patients [57,102], while CRHR2 stimulation by Ucn2 in human colonocytes resulted in NF-κB pathway activation and increased secretion of IL-8 and MCP-1 [102,109]. Here, CXCL8 is linked to irritable bowel syndrome.