Levels of mucosal cell-derived Ucn1 were found lower in biopsies from GC-treated IBD patients and higher in cases of more severe inflammation, while in CD-derived biopsies the epithelial expressions of CRHR2 and Ucn2 were increased in regions of active inflammation as compared to non-inflamed intestinal regions [9,102,106]. This evidence concerns the gene UCN2 and irritable bowel syndrome.