CRHR2 and irritable bowel syndrome: Given that Ucn2 has been implicated in supporting topical inflammation, through induction of IL-6 [199], we hypothesized that under minimal CRHR2 expression the high Ucn2 levels detected in CRC tissues and cell lines, might contribute in maintaining and/or promoting IL-6 expression, thus serving as an inflammatory stimulus supportive for IBD-related carcinogenesis.