Similar to the proinflammatory TH1 cytokines, TH17 cytokines such as IL-17A, IL-17F, and IL-22 have a major impact on epithelial cells in various tissues and are important in mediating mucosal immunity, particularly against Gram-negative bacteria and fungal infections, by inducing neutrophil chemotaxis [11,12,13,14]. The gene discussed is IL17A; the disease is fungal infectious disease.