On the other hand, PAX2 is expressed in ovarian cancer, renal-cell carcinomas (RCC) and in some bladder carcinomas, where it is crucial for tumor survival since PAX2 regulates the surface protein metallopeptidase, A Disintegrin and metalloproteinase-domain containing protein 10 (ADAM10) [133]. This evidence concerns the gene PAX2 and hereditary clear cell renal cell carcinoma.