HMGB1 and hepatocellular carcinoma: The mRNA and protein expression levels of HMGB1 are increased in the lungs of patients with NSCLC, pancreatic ductal adenocarcinoma (PDAC), gastric cancer, colorectal cancer, hepatocellular carcinoma (HCC), and correlate with disease development, tumor progression, invasion, poor prognosis, and metastasis [107] (Table 1).