Meanwhile, limonin can also exert therapeutic effects on mice with idiopathic pulmonary fibrosis by suppressing the expression of iNOS, intercellular cell adhesion molecule-1 (ICAM1), vascular cell adhesion molecule 1 (VCAM1), and COX2, and attenuating oxidative stress in bleomycin-induced lung tissues [94]. The gene discussed is VCAM1; the disease is pulmonary fibrosis.