In addition, some researchers have also found that limonin can induce apoptosis of breast cancer cell line MDA-MB-231 by inducing ser 468 phosphorylation of nuclear factor kappa-B (NF-κB) pathway to stimulate the expression of apoptotic genes, and considered that limonin to be beneficial in breast cancer patients receiving chemotherapy [28]. Here, NFKB1 is linked to breast carcinoma.