As expected, 48 h infection of myotubes with caFoxO3-encoding viruses reduced overall RNA content by about 50% (Figure S1a), overall protein synthesis by 12% (Figure 1c) and increased the rates of long-lived protein degradation per hour by about 11% (Figure 1e), by enhancing both atrogin-1 and MuRF1 expression (Figure S2a–c). The gene discussed is TRIM63; the disease is infection.