As such, these different dynamics of AKT activation [42,50,51,52,53] could result in the observed discrepancies of the downstream signaling and explain the differences from our results, where musclin was not induced by MyrAKT in vitro in four day-differentiated immortalized C2C12 myotubes at any time tested (24, 48 and 72 h post-infection). Here, OSTN is linked to infection.