RAPGEF1 and colorectal adenocarcinoma: The impacts of C3G-Ms on apoptosis are similar to C3G, and multiple studies have suggested that PCA [35,36,100] and FA [110,111] may act against apoptosis in various models, although other studies revealed that C3G-Ms (PCA, FA) might promote apoptosis of colorectal adenocarcinoma cells [112].