Other findings provide support that RSG is able to counteract AD-associated cognitive decline Indeed, RSG ameliorates hippocampal cognitive deficits in some AD patients, and counteracts cognitive deficits in the Tg2576 mouse model for AD amyloidosis through PPARγ signaling activation and ERK cascade, a key mediator for memory consolidation [35]. The gene discussed is MAPK1; the disease is Alzheimer disease.