In this HD model, RSG is able to induce the expression of B-cell lymphoma 2 (Bcl-2) and BDNF, as well as inhibiting huntingtin aggregates, and restoring to normal levels the expression of PGC1α, nuclear respiratory factor 1-2 (NRF1-2), and mitochondrial transcription factor A (TFAM) in the transgenic mouse R6/2 cortex. This evidence concerns the gene BDNF and Huntington disease.