Elevated levels of MG are found in cerebrospinal fluid of patients with neurodegenerative disorders, e.g., those with AD [31], wherein induces hyper phosphorylation of Tau by enhancing kinase activities (i.e., GSK3β) and/or reducing levels of phosphatase (i.e., those of protein phosphatase 2A) [31]. The gene discussed is GSK3B; the disease is Alzheimer disease.