Coordination between the inhibition of HDAC1 and the activation of the histone demethylase Lysine-specific demethylases 6 (KDM6B/JMJD3A) and KDM6A/UTX activates brown adipocyte genes and prevents the appearance of obesity [106,107]. The gene discussed is KDM6A; the disease is obesity due to melanocortin 4 receptor deficiency.