CALCR and central nervous system cancer: In another study, SO1861 was combined with chemical conjugates of dianthin-30 and a monoclonal anti-calcitonin receptor antibody and tested on high-grade glioma cell lines SB2b, JK2 and U87MG, resulting in IC50 values of 0.01 nM, 0.01 nM and 0.02 nM [85] (Table 5).