PPARA and metabolic disease: Although the evidence presented herein is by no means exhaustive, it is undeniable that the clinical implications of PPAR agonists span a wide range of health conditions, ranging from metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological, and psychiatric disorders, malignancies, etc. Such an extensive implication of PPAR agonists also signifies the crucial modulatory roles of PPARs in diseases with varying pathogeneses.