PPARA and type 2 diabetes mellitus: Despite the setbacks of muraglitazar, tesaglitazar, and aleglitazar, the development of dual- and pan-PPAR agonists in metabolic diseases is gradually gaining momentum, as exemplified by chiglitazar (for T2DM), saroglitazar (for dyslipidemia), and elafibronor (for dyslipidemia).