TP53 and gastric cancer: According to the Cancer Genome Atlas (TCGA) project, tumor protein p53 (TP53) and myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4) mutations occur with the highest frequencies in gastric cancer, but gene alterations of members of the human epidermal growth factor receptor family (HER3, ERBB4 and EGFR) are also prevalent in gastric cancer and are considered to be important driver mutations [26].