Hcf-1 is required for productive AcMNPV infections in nonpermissive Tn368 cells [34,35]; HCF-1 is an early protein that localizes to the cell nucleus [36], and promotes the replication of recombinant BmNPV in nonpermissive Tn368 cells [37]. The gene discussed is HCFC1; the disease is infection.