KRAS and neoplasm: The rat sarcoma (RAS) pathway was reported to have an important effect on the Cdk5-mediated tumor progression on the one hand because mutant Kirsten rat sarcoma (KRAS) increased its kinase activity [7] and on the other hand, by participating in its downstream signaling through phosphorylation of Ras-related (Ral) A and B proteins [11].