In the present study, we studied the role of Cdk5 in several CRC cell lines, reproducing results from Zhuang et al. [13] and most importantly, we investigated the expression patterns of Cdk5 at different molecular levels in a significant number of human tumor samples from patients at different disease stages with the aim of evaluating its role as a prognostic and predictive marker in this malignancy. Here, CDK5 is linked to colorectal carcinoma.