EP300 and breast cancer: Together, these data indicate that PARP1 co-regulates activity of promoter-bound BRG1–EP300 complexes, and that poly-ADP-ribosylation of EP300 is required to enable the BRG1-dependent eviction of acetylated nucleosome, and therefore the transcription of genes involved in key intracellular processes, such as cell division and the removal of DNA damage in breast cancer cells.