EP300 and breast carcinoma: Bearing in mind that the BRG1/EP300 complex was shown to operate at gene promoters in proliferating breast cancer cells and human macrophages due to an association with E2F transcription factors [12,26], the same PARP1-dependent mechanism of transcription control likely applies to other tumors, since the cell cycle status conditions both PARP1 expression and the activity of BRG1–EP300 complexes.