Transforming growth factor β (TGF-β) and chemokines like CXCL8 (IL-8), CXCR3, Rantes, and CCR8 were also found downregulated in SM cases by the fold change reduction values of 1.53, 1.25, 1.98, 3.08, and 5.69, respectively, compared to endemic control. The gene discussed is CCR8; the disease is systemic mastocytosis.